Please use this identifier to cite or link to this item: http://localhost:8080/xmlui/handle/123456789/565
Title: Tenofovir-associated renal toxicity in a cohort of HIV infected patients in Ghana
Authors: Nartey, Edmund T.
Tetteh, Raymond A.
Yankey, Barbara A.
Mantel‑Teeuwisse, Aukje K.
Leufkens, Hubert G. M.
Dodoo, Alexander N. O.
Lartey, Margaret
Keywords: Tenofovir disoproxil fumarate
Renal dysfunction
Creatinine clearance
HIV
ART
Issue Date: 2019
Publisher: BMC research notes
Citation: Nartey, E. T., Tetteh, R. A., Yankey, B. A., Mantel-Teeuwisse, A. K., Leufkens, H. G., Dodoo, A. N., & Lartey, M. (2019). Tenofovir-associated renal toxicity in a cohort of HIV infected patients in Ghana. BMC research notes, 12, 1-6.
Abstract: Objective: Tenofovir disoproxil fumarate (TDF) is a nucleotide analogue recommended in international HIV treat‑ ment guidelines. Purpose of this study was to estimate the long term efects of TDF on renal profle in a cohort of HIV patients in Ghana. Three hundred (300) consecutive HIV-positive patients who initiated TDF-based antiretroviral treat‑ ment in 2008 at the Korle-Bu Teaching Hospital were sampled. Creatinine clearance (CrCl) was calculated using the Cockcroft-Gault equation at baseline and renal impairment was defned as CrCl values of 30.0–49.9 mL/min (moder‑ ate renal impairment) and<30 mL/min (severe renal impairment) as per institutional guidelines for renal function test. Results: Median follow up time was 2.9 years (IQR 2.3–3.4 years). At study endpoint, 63 participants (21.0% [95% CI 6.5–26.1]) recorded CrCl rate below 50 mL/min indicating incident renal impairment, made up of 18.3% moderate renal impairment and 2.3% severe renal impairment. Factors associated with incidence of renal impairment were increasing age, decrease in creatinine clearance rate at baseline, WHO HIV stage III/IV and participants with BMI of<18.5 kg/m2 . Patients with identifed renal impairment risk factors at ART initiation should be targeted and moni‑ tored efectively to prevent renal injury.
URI: https://doi.org/10.1186/s13104-019-4454-2
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